免疫类型组用于全面描述侵袭性甲状腺癌的免疫类型组.
Mihail Ceausu1,2, Mihai Alin Publik1, Dana Terzea1
1Department of Pathology, "C.I. Parhon" National Institute of Endocrinology, 011863 Bucharest, Romania.
Cells
|October 15, 2025
概括
侵袭性甲状腺癌,包括塑性 (ATC) 和差分化 (PDTC),表现出不同的免疫类型. 失去TTF-1和PAX-8标记物,以及高的Ki-67,表明有侵略性的厌塑性转变.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 分子生物学分子生物学
背景情况:
- 侵袭性甲状腺癌,如阿纳塑性 (ATC) 和差分化 (PDTC),是罕见的,致命的,缺乏标准化的诊断算法.
- 不完整的免疫类型特征阻碍了对这些侵袭性瘤的有效诊断和治疗策略.
研究的目的:
- 综合描述侵袭性甲状腺癌 (ATC和PDTC) 的免疫表型.
- 为了识别形转变的诊断标记,并预测瘤的攻击性.
- 探索特定突变 (BRAFV600E,TERT) 与标记物表达之间的关联.
主要方法:
- 在2014-2024年间对40例甲状腺切除术 (12例ATC,28例PDTC) 的回顾性分析.
- 评估临床数据,组织病理学,分子分析 (BRAFV600E,TERT突变) 和免疫组织化学 (BRAF,K-RAS,TERT,PAX-8,TTF-1,P53,Ki-67) 的研究.
主要成果:
- 在70%的病例中发现了BRAFV600E突变,在ATC中更多. TERT异常表达超过了90%.
- TTF-1和PAX-8的损失与亚塑性转化相关. 在ATC中较高的Ki-67指数表明了侵略性.
- 多变量分析确定了TTF-1的损失和瘤缩作为形组织型的预测因素.
结论:
- 针对BRAFV600E的免疫组织化学可以选突变. 经常发生BRAFV600E和TERT突变,特别是在PDTC中.
- 在侵袭性甲状腺癌中,BRAF/RAF激活,TTF-1/PAX-8损失,TERT上调和TP53改变是常见的.
- 失去TTF-1和亡是分类侵袭性甲状腺癌的关键指标.
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