在老年糖尿病患者中,阿迪波涅丁和营养指数与肉症的关联
Aruna Raju1, Jean Fredrick1, Asmita Hazra2
1Department of Physiology, All India Institute of Medical Science, Kalyani, West Bengal, India.
Journal of basic and clinical physiology and pharmacology
|October 15, 2025
概括
老年糖尿病患者患有肉症的阿迪波涅克丁水平较高,营养状况较差. 在这个人群中,阿迪波涅丁可以作为肌肉消耗的生物标志物.
科学领域:
- 老年学是一门学科.
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 标志着肌肉质量和力量损失的萨尔科佩尼亚,在老年人中普遍存在,特别是那些患有糖尿病的人.
- 阿迪波尼克丁是一种阿迪波金,在新陈代谢和炎症中具有复杂的作用,其与糖尿病老年人肉症的关联尚未完全阐明.
研究的目的:
- 在老年糖尿病患者中研究血清阿迪波涅克水平,营养状况和肉症之间的关系.
- 为了确定潜在的代谢和营养生物标志物区分sarcopenic和非sarcopenic个体在这个队列.
主要方法:
- 一项涉及80名老年糖尿病患者 (>60岁) 的横截面研究,分为sarcopenic (n=40) 和非sarcopenic (n=40) 组.
- 评估血清脂肪素,葡萄糖代谢标志物,脂质样本和营养指数 (预后营养指数[PNI],老年营养风险指数[GNRI],控制营养状况[CONUT]得分).
主要成果:
- 麻症患者表现出显著更高的阿迪波涅丁水平 (12.8比8.4微克/毫升) 和胰岛素敏感性受损 (QUICKI:0.31比0.36).
- 所有的营养指数 (PNI,GNRI,CONUT) 在肉群体中显著下降.
- 素,年龄,胰岛素耐药性和营养指数独立预测了sarcopenia.
结论:
- 相反,较高的阿迪波涅丁水平与老年糖尿病患者的肉症有关,这表明它可能是肌肉衰竭的生物标志物.
- 营养指数和肉症之间的强烈联系强调了对这一患者群体进行综合营养评估的迫切需要.
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