在患有癌症的个体中对梅奥 Delirium 预测工具的外部验证
Noman Ali1, Lara Magnabosco2, Tacara Soones2
1Department of Hospital Medicine, UT MD Anderson, Houston, TX.
Mayo Clinic proceedings
|October 15, 2025
概括
梅奥狂妄症预测 (MDP) 工具有效预测住院癌症患者的狂妄症风险,在外科病例中表现更强,而在医学病例中表现更强. 建议针对临床实践量身定制的风险截止值.
科学领域:
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 关键护理医学 关键护理医学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 痴呆症是住院癌症患者的常见并发症,与不良结果有关.
- 早期准确预测妄风险对于及时干预至关重要.
- 梅奥痴呆症预测 (MDP) 工具在一般医院人群中显示出有前途.
研究的目的:
- 在一组住院癌症患者中验证Mayo Delirium预测 (MDP) 工具的预测准确性.
- 评估MDP工具在区分医疗和外科瘤患者方面的性能.
- 评估MDP工具对癌症护理中狂妄症风险分层的有用性.
主要方法:
- 对930名住院癌症患者 (≥50岁) 的回顾性验证研究.
- 在入院后24小时内从电子健康记录中提取重新校准的MDP变量.
- 用接收器操作特征曲线,灵敏度,特异性,PPV和NPV评估医疗和外科服务的预测准确性.
主要成果:
- 多元化发展计划工具显示了良好的整体预测准确性 (AUC,0.8047).
- 与医学患者 (AUC,0.7867) 相比,在手术患者 (AUC,0.9488) 中观察到更高的预测准确度.
- 灵敏度和特异性根据所选择的风险截止分数大大不同,这表明在高风险和低风险水平上的性能差异.
结论:
- 该MDP工具是预测住院癌症患者 Delirium 风险的一个有能力的工具.
- 该工具的预测性能在外科瘤患者中显著更强.
- 临床实施需要仔细考虑风险截止值,以优化MDP工具的应用.
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