在风湿性关节炎患者中检测间歇性肺病的三个风险评分曲线下的可比面积:外部验证
Elin Blomberg1, Bengt Wahlin1, Anna Södergren2
1Department of Public Health and Clinical Medicine / Rheumatology, Umeå University, Umeå, 901 87, Sweden.
Rheumatology international
|October 15, 2025
概括
经过验证的风险评分可以识别风湿性关节炎患者的间歇性肺部疾病 (RA-ILD) 风险. 在这个瑞典北部队列中,MUC5B基因变异很常见,但与亚临床肺部问题无关.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 遗传学 遗传学 是一个
背景情况:
- 类风湿性关节炎相关的间歇性肺病 (RA-ILD) 在类风湿性关节炎 (RA) 患者的发病率和死亡率显著增加.
- MUC5B基因促进器变体是发展RA-ILD的已知危险因素.
- 现有的风险评分旨在识别易受RA-ILD的RA患者.
研究的目的:
- 为了外部验证预测RA-ILD的三个已建立的风险评分.
- 为了确定北瑞典RA队列中MUC5B促进体变异的频率.
- 研究RA患者MUC5B变异与亚临床肺部变化之间的关联.
主要方法:
- 外部验证的法官等人,惠勒等人,和科杜里等人. 使用二进制物流回归和AUC ROC分析进行RA-ILD风险评分.
- 在瑞典北部的54名RA患者中对MUC5B促进体变异进行基因型定型.
- 统计分析以评估MUC5B变种与亚临床肺部疾病之间的关联.
主要成果:
- 这三种风险得分都显示出良好的表现:AUCROC为0.71 (Juge等. ),0.75 (Wheeler和其他人. ) 和0.70 (科杜里等人). ) 的情况.
- 在26%的队列中存在MUC5B促销器变异.
- 在这个队列中,MUC5B变异和亚临床肺部变化之间没有发现显著的关联.
结论:
- 对RA-ILD的外部验证的风险评分是可靠的,在临床实践中对风险分层有潜在的有用性.
- 虽然MUC5B发起体变异是普遍存在的,但在瑞典北部的人群中,它与亚临床RA-ILD没有独立相关.
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