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对电离辐射诱导的玻璃眼系统性审查:临床表现,病原和当前的治疗方法

Anqi Wu¹, Xinyan Huai¹, Qiwen Zhou¹

¹School of Basic Medical Sciences & School of Public Health, Faculty of Medicine, Yangzhou University, Yangzhou, China.

Cutaneous and ocular toxicology

|October 15, 2025

概括

电离辐射诱导的玻璃眼 (IRG) 呈现为新血管玻璃眼 (NVG) 或正常张力玻璃眼 (NTG),取决于辐射剂量. 目前的治疗方法提供了有限的益处,需要进一步研究机制和基于证据的管理策略.

科学领域:

眼科医生眼科眼科
辐射瘤学辐射瘤学
玻璃眼研究研究玻璃眼研究

背景情况:

电离辐射诱导的玻璃眼 (IRG) 是放射治疗的一种罕见但严重的并发症.
它表现为高剂量后的新血管玻璃眼 (NVG) 和低剂量后的正常张力玻璃眼 (NTG).
了解IRG的剂量反应,机制和管理对于患者护理至关重要.

研究的目的:

审查对电离辐射诱导青光瘤 (IRG) 的临床谱,病变发生和治疗方法.
识别知识上的差距,并为未来的研究方向提供信息.
为制定标准化管理协议提供基础.

主要方法:

在主要数据库 (PubMed/MEDLINE,Embase,Scopus,Cochrane) 中进行了系统的文献搜索.
搜索涵盖了1964年至2024年的出版物,遵守PRISMA指南.
在7256篇选文章中,选出了37项相关研究.

主要成果:

NVG (>30 Gy) 涉及视网膜缺血和新血管化,通常发生在阴膜黑色素瘤患者中.
NTG (<1 Gy) 导致视神经损伤和视野损失,而没有压力升高.
诸如抗VEGF,管切除术和排水装置等治疗方法的疗效和并发症各不相同.

结论:

IRG是一种剂量依赖的疾病,具有不同的临床表现和潜在机制.
现有的疗法部分有效,但缺乏标准化和长期耐用性.
预防策略和基于证据的治疗算法需要进一步的机制研究和精心设计的临床试验.

关键词:

抗VEGF治疗疗法是一种治疗方法.电离辐射诱导的玻璃眼 (IRG)神经血管玻璃眼 (NVG)正常张力玻璃眼 (NTG) 是一种正常张力玻璃眼.氧化压力是一种氧化压力.

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