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一个新的肥胖定义的含义在我们所有人的队列中
Lindsay T Fourman1, Aya Awwad1, Alba Gutiérrez-Sacristán2
1Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston.
JAMA network open
|October 15, 2025
概括
结合BMI和人体测量学的新肥胖定义显著增加了患病率,识别了患有器官功能障碍和糖尿病和心血管疾病等长期健康问题的风险较高的人.
科学领域:
- 内分泌学和新陈代谢学
- 公共卫生和流行病学
- 临床医学 临床医学
背景情况:
- 已经提出了一个新的肥胖定义,将体重指数 (BMI) 与人体测量指数结合起来,从而改变了分类范式.
- 传统的BMI值可能低估了肥胖患病率和相关的健康风险.
研究的目的:
- 评估新型肥胖定义的临床影响.
- 确定新定义如何影响肥胖患病率和风险分层.
主要方法:
- 一项基于人口的纵向队列研究,使用来自我们所有人队列 (N=301,026) 的数据.
- 参与者被跟踪了平均4.0年.
- 肥胖症使用传统的BMI和新的定义进行分类,包括BMI加人类计量和人类计量仅肥胖症,根据器官功能障碍分类为临床或临床前.
主要成果:
- 新定义发现,与传统定义 (42.9%) 相比,肥胖的患病率更高 (68.6%).
- 根据新框架定义的临床肥胖症在36.1%的队列中流行,随着年龄的增长而增加.
- 新的肥胖分类与器官功能障碍的几率显著增加以及发生糖尿病,心血管事件和全因死亡率的风险增加有关.
结论:
- 采用新的肥胖定义会大幅增加患病率,并对临床和公共政策产生重大影响.
- 新的框架有效地识别了器官功能障碍和长期并发症的高风险个体.
- 只有人体测量和临床前肥胖症被确定为需要进一步调查的不同实体.
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