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Updated: Jan 15, 2026

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
07:49

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Published on: July 17, 2019

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针对RAS突变特异性反应对相对和状态选择性RAS抑制剂的反应

Beau Baars1, Ana Orive-Ramos1, Matthew J Emmett2,3,4

  • 1Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Molecular cancer research : MCR
|October 15, 2025
PubMed
概括

大多数针对RAS的癌症疗法由于选择性差,其有效性有限. 评估信号抑制指数 (SII) 显示,与正常细胞相比,许多当前的RAS抑制剂很难抑制瘤细胞中的瘤信号.

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