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Updated: Jan 15, 2026

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小分子OPA1抑制剂可以逆转线粒体的适应性,以克服急性髓性白血病的治疗阻力

Sofia La Vecchia1,2,3, Saurav Doshi1,2,3, Petros Antonoglou1,2,3

  • 1Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

Science advances
|October 15, 2025
PubMed
概括

新的研究表明,抑制视力缩1 (OPA1) 可以克服急性髓性白血病 (AML) 的耐药性. OPA1抑制剂与venetoclax协同作用,为治疗这种致命癌症提供了一个有希望的策略.

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