在多发性硬化症中用于免疫重编程的纳米颗粒增强的髓衍生抑制细胞疗法
Endong Zhang1, Hanan Algarni1, Luyu Zhang1
1Department of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, IL, USA.
Science advances
|October 15, 2025
概括
使用载有纳米颗粒的髓质衍生抑制细胞 (MDSC) 的新疗法为诸如多发性硬化症等中枢神经系统 (CNS) 疾病提供了针对性的免疫重编程. 这种方法有效地减少了炎症和疾病的进展.
科学领域:
- 神经免疫学 神经免疫学
- 翻译医学是一种翻译医学.
- 药物输送系统 药物输送系统
背景情况:
- 多发性硬化症 (MS) 的特征是免疫细胞透和中枢神经系统 (CNS) 的慢性炎症.
- 目前的治疗策略旨在调节免疫反应,但往往缺乏针对性向中枢神经系统传递.
研究的目的:
- 开发和评估一种基于骨髓原抑制细胞 (MDSC) 的新型治疗策略,用于中枢神经系统中针对性免疫重编程.
- 评估这种策略在多发性硬化症的实验性自身免疫脑膜炎 (EAE) 模型中的有效性.
主要方法:
- 开发一种名为CNS Immune Targeting Enabled by MDSCs (CITED) 的疗法,使用装饰着拉巴胺纳米颗粒 (NP) 的MDSC.
- 评估NP装饰的MDSCs对增强的免疫调节功能,中枢神经系统贩运和NP积累.
- 在EAE小鼠模型中评估CITED的治疗疗效,测量疾病进展,运动功能和髓损伤.
主要成果:
- NP装饰增强了MDSC免疫调节能力,并促进了针对性地向炎症中枢神经系统区域输送.
- 在EAE模型中,CITED治疗显著降低了疾病进展,改善了运动功能,并最大限度地减少了髓损伤.
- 机理学研究证实CITED能够抑制免疫细胞透,重新平衡CD4T细胞表型,并促进抗炎性髓状细胞两极化.
结论:
- 根据CITED战略,通过在中枢神经系统内实现针对性免疫恢复,证明了多发性硬化症的强大治疗潜力.
- 这种方法为调节中枢神经系统自身免疫性疾病中的先天性和适应性免疫反应提供了一个广泛有效的方法.
更多相关视频
11:37Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting
Published on: June 18, 2018
7.1K
10:04Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
Published on: August 1, 2025
1.5K
相关概念视频
Receptor-mediated Endocytosis
Overview
Smooth Endoplasmic Reticulum
Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
Liver Regeneration
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Liver Histology
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Hepatocytes perform a variety of essential functions. They secrete...
Lipid Absorption
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
Lipid Catabolism
Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
