杆菌和阿尔茨海默病风险:HUNT研究
Pieta T Kelsey1,2, Geir Selbæk3,4,5, Hugo Lövheim6
1HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
在挪威的一项大型研究中,Helicobacter pylori感染与阿尔茨海默病 (AD) 或痴呆症的风险增加无关. 然而,H. pylori阳性与更高的全因死亡率有关.
科学领域:
- 神经科学是一个神经科学.
- 传染病流行病学 传染病流行病学
- 老年学是指老年学的学科.
背景情况:
- 感染被假设在阿尔茨海默氏病 (AD) 发病过程中发挥作用.
- 之前关于Helicobacter pylori (H. pylori) 感染与AD或痴呆症之间的联系的研究已经产生了相互矛盾的结果.
研究的目的:
- 调查H. pylori血清学与发展AD和痴呆症的风险之间的关联.
- 为了检查H. pylori感染和全因死亡率之间的关系.
主要方法:
- 利用了来自特伦德拉格健康研究 (HUNT) 的数据,测量了H. pylori抗体标位.
- 在采样22年后,使用标准化测试和代理访谈进行认知评估.
- 使用后勤和考克斯回归模型来分析认知结果和死亡率,并进行子组分析和协变量调整.
主要成果:
- 在H. pylori标位或血清阳性与阿尔茨海默病或痴呆症风险之间没有发现显著的关联.
- 按性别,年龄,Apolipoprotein E4 (APOE ε4) 状态和C反应性蛋白水平进行分层分析,没有发现任何关联.
- H. pylori 阳性与统计学上显著增加全因死亡率有关.
结论:
- 杆菌感染与患阿尔茨海默氏症或痴呆症的风险增加无关.
- 需要进一步的研究来澄清感染负担和神经退行性疾病之间的复杂关系.
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