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¹Department of Intensive Care Unit, First People's Hospital of Jining, Shandong, China.

Journal of intensive care medicine

|October 15, 2025

概括

败血症相关脑病变 (SAE) 与肠道微生物群失衡和代谢物改变有关,影响大脑功能和免疫力. 针对这些肠道衍生因素为SAE提供了潜在的治疗策略.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
免疫学免疫学免疫学

背景情况:

败血症相关脑病变 (SAE) 是败血症的常见并发症,结果不佳.
肠道微生物群失调和变化的代谢物概况越来越多地与SAE病原发生有关.
将肠道变化与SAE联系起来的神经免疫机制需要进一步阐明.

研究的目的:

审查目前对SAE肠道微生物群干扰的理解.
探索改变的小分子代谢物的作用,包括短链脂肪酸 (SCFA),在SAE.
总结神经免疫炎症变化和SAE潜在的治疗干预措施.

主要方法:

对调查肠-大脑轴在败血症中的研究的文献综述.
对微生物代谢物及其对血脑屏障完整性的影响的研究分析.
在SAE期间检查免疫系统在中枢和外周神经系统的激活.

主要成果:

肠道菌群失衡和代谢变化与SAE有关.
像SCFA这样的代谢物的变化会影响大脑平衡和神经炎症.
SAE涉及血脑屏障透性的改变和免疫细胞的激活.

结论:

肠道微生物群,代谢物概况和神经免疫炎症是SAE的关键因素.
潜在的治疗目标包括调节肠道微生物群,代谢物水平或神经刺激.
对这些机制的进一步研究可能会揭示SAE的新型治疗策略.

关键词:

肠道菌群的干扰肠道菌群的干扰代谢物的代谢物.神经炎症是一种神经炎症.败血症相关的脑病变 - 脑病变.

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