更年期,雌激素和GERD:对症状和内镜相关性的探索
Praveena Meyyazhagan1, Pavitra Vyshnavi Yogisparan2, Thendral Anandaraj3
1Department of Physiology, 597930 Trichy SRMMCH&RC , Trichy, India.
Journal of basic and clinical physiology and pharmacology
|October 15, 2025
概括
绝经后的女性由于雌激素水平较低,经历了更严重的胃食道逆流性疾病 (GERD) 症状. 这种荷尔蒙变化与老年女性GERD患病率增加和内镜检查结果相关.
科学领域:
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
- 妇女健康 妇女健康
背景情况:
- 胃食道逆流性疾病 (GERD) 是一种影响生活质量的常见疾病.
- 荷尔蒙的波动,特别是雌激素水平,可能会影响GERD症状.
- 更年期代表着女性生活中显著的荷尔蒙转变.
研究的目的:
- 为了研究雌激素水平和GERD症状严重程度在绝经前与绝经后妇女之间的关系.
- 为了将荷尔蒙状况与GERD患者的内镜检测结果相关联.
- 为了确定与更年期状态相关的GERD模式.
主要方法:
- 在胃肠机动性实验室进行的研究, PSGIMS&R, Coimbatore.
- 获得了机构人类道德委员会 (IHEC) 的批准.
- 对雌激素水平和内镜检查结果与更年期状态相关的分析.
主要成果:
- 在绝经前妇女 (82.80150.43 pg/mL) 和绝经后妇女 (6.0517.30 pg/mL) 之间观察到雌激素水平的显著差异.
- 绝经后妇女的雌激素水平较低与GERD症状的增加有关.
- 绝经后妇女更常见的是内镜异常,与荷尔蒙下降相关.
结论:
- 绝经后雌激素水平降低与更高的GERD患病率和症状严重程度有关.
- 胃炎和消化不良是绝经后妇女更常见的GERD症状.
- 荷尔蒙变化是GERD严重程度的一个重要因素,需要对风险因素进行评估.
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