吸烟与杜普伊特伦收缩之间的关联:系统性审查和元分析
Brandon S Chai1, Meghan He2, Alexis E Mah3
1Division of Plastic and Reconstructive Surgery, University of British Columbia, Vancouver, Canada.
Plastic and reconstructive surgery
|October 15, 2025
概括
吸烟显著增加患杜普伊特伦病的几率. 这一元分析证实,任何有吸烟史的个体的风险增加了1.5倍,这突显了戒烟的重要性.
科学领域:
- 医学研究 医学研究
- 流行病学 流行病学
- 类风湿病学 类风湿病学
背景情况:
- 吸烟被怀疑是杜普伊特伦病的危险因素,但证据仍然不确.
- 该协会的方向性和实力需要进一步量化.
研究的目的:
- 系统地评估和量化吸烟与杜普伊特伦病发病率之间的关联.
- 提供强有力的证据,证明吸烟是这种疾病的危险因素.
主要方法:
- 进行了全面的系统数据库搜索,以确定相关的比较研究.
- 使用随机效应模型的双对元分析用于汇集22项研究的数据.
- 分析包括超过150万名参与者 (吸烟者和非吸烟者).
主要成果:
- 杜普伊特伦病的发病率在吸烟者中为5.6%,而非吸烟者中为4.4%.
- 目前活跃吸烟者的几率增加了1.45倍 (OR 1.45,95% CI 1.06-1.98).
- 任何吸烟史都会增加1.5倍的几率 (OR 1.50,95% CI 1.20-1.88),这与灵敏度分析相一致.
结论:
- 吸烟和杜普伊特伦病之间存在统计学上显著的关联.
- 建议杜普伊特伦病患者戒烟.
- 需要进一步的研究来确定戒烟是否会影响疾病的进展或复发.
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