心室 - 动脉合和全球纵向应变之间的相关性在高血压患者中,具有保存的射出分数
1Special Medical Service Centre, Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
American journal of hypertension
|October 15, 2025
概括
用Ea/Ees测量的心室动脉合 (VAC) 与高血压患者的左心室 (LV) 全球纵向应变 (GLS) 有关. 这表明Ea/Ees可以预测亚临床LV缩功能障碍.
科学领域:
- 心脏病学 心脏病学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
- 心血管生理学心血管生理学
背景情况:
- 来自斑点跟踪心声学 (STE) 的全球纵向应变 (GLS) 检测到左心室 (LV) 缩功能障碍.
- 室腔动脉合 (VAC) 评估心血管效率.
- 在高血压患者中,VAC和GLS之间的关系与保存的喷射分数 (EF) 尚不清楚.
研究的目的:
- 调查心室动脉合 (VAC) 和全球纵向应变 (GLS) 之间的关联.
- 为了检查这种关系,特别是在高血压患者和保存LV喷射分数 (EF) 的高血压患者.
主要方法:
- 一项涉及104名高血压患者和40名对照者的横截面研究.
- VAC计算为有效动脉弹性 (Ea) 与末性弹性 (Ees) (Ea/Ees) 的比.
- 使用2D STE进行GLS评估;Ea/Ees被分类为三维分析.
主要成果:
- 在GLS和Ea/Ees tertiles之间发现了显著的负相关性 (β = -0.276,P = 0.005).
- 在调整为混变量 (β = -0.237,P = 0.007) 之后,这种关联仍然显著.
- Ea/Ees显示了异常GLS的预测值 (AUC=0.656,P=0.010).
结论:
- 在高血压患者中,Ea/Ees与GLS独立相关,LV EF保存.
- 使用GLS,Ea/Ees可以作为潜在的生物标志物来检测亚临床LV缩功能障碍.
- 研究的注册号:NCT04573257.7. 研究的注册号:NCT04573257.
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