手握强度和临床前肥胖进展的轨迹:使用英国生物银行进行的多州模型分析

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Manrong Xu¹, Menghan Li¹, Yawen Zhang¹

¹Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China.

The Journal of clinical endocrinology and metabolism

|October 15, 2025

概括

较高的握力与患临床前肥胖症和相关健康问题的风险较低有关. 这凸显了肌肉力量对整体健康和寿命的重要性.

科学领域:

公共卫生公共卫生
老年学是一门学科.
代谢健康代谢健康

背景情况:

握力是慢性疾病风险和死亡率的公认指标.
了解其在临床前肥胖症进展中的作用对于预防策略至关重要.

研究的目的:

调查握力与临床前肥胖症进展之间的关联.
检查患有临床前肥胖症的个体中握力和多种原因死亡风险之间的联系.

主要方法:

利用了来自93275名参与者的英国生物库数据.
使用人类参数 (BMI,腰围等) 定义的临床前肥胖症. 没有现有的功能障碍.
采用多状态模型来分析握力与肥胖症进展轨迹和死亡率的关联.

主要成果:

每次SD增加握力都显著降低了所有阶段临床前肥胖症进展的风险.
在所有轨迹模型中,最高的抓地强度三级显示出保护作用.
在子组和敏感性分析中观察到一致的结果,加强了研究结果.

结论:

增加握力显著与减低肥胖引起的功能障碍进展和死亡率的风险有关.
改善肌肉质量和力量对于肥胖的临床前阶段的人来说至关重要.

关键词:

英国生物银行.所有原因的死亡率.抓地力抓地力抓地力抓地力多州模式的模型.肥胖引起的功能障碍临床前肥胖症临床前肥胖症

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