耳前心肌病:标志物和结果
Oliver B Vad1,2,3, Nick van Vreeswijk1, Ahmed S Yassin1
1Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
心房心肌病 (AtCM) 影响七分之一的人,并与心房动 (AF),心力衰竭 (HF) 和中风的风险增加有关. 识别AtCM标志物可以改善对这些心血管疾病的风险预测.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 流行病学 流行病学
背景情况:
- 心房心肌病变 (AtCM) 越来越被认为是导致心房动 (AF) 的重要因素.
- 了解AtCM的风险因素及其与主要心血管事件的关联对于临床实践至关重要.
研究的目的:
- 调查AtCM的潜在标志物和风险因素.
- 评估AtCM与发生的AF,心力衰竭 (HF) 和中风的关联.
- 评估AtCM标志物在心血管风险预测中的附加值.
主要方法:
- 利用英国生物库数据与26467人的心脏MRI和心电图信息.
- 定义的AtCM标志物包括左心房扩张,机械功能障碍,P波延长和异常的P波终端力.
- 用于风险因素的物流回归和Cox回归/累积发病率模型的结果,整合临床和遗传风险得分.
主要成果:
- 15.7%的人至少有一种AtCM标志物;2.3%的人有两种或更多.
- AtCM标志物与AF (HR:4.59对于≥2标志物),HF (HR:3.08) 和中风 (HR:3.07) 的危险比率显著增加有关.
- 添加AtCM标志物使AF风险重新分类提高了13.7% (NRI).
结论:
- 心房心肌病是一种普遍的疾病,每七个人中就有一个有标志物.
- AtCM标志物独立地与AF,HF和中风的风险增加有关.
- AtCM作为这些心血管结果的常见病理生理基质,增强风险预测模型.
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