虹膜素缺乏会加剧心脏功能障碍,并在出血/复苏过程中增加出血损伤
Supaporn Kulthinee1,2, Lijiang Wang1,2, John Slate-Romano1,2
1Department of Surgery, Rhode Island Hospital, The Warren and Alpert Medical School of Brown University, Providence, Rhode Island, United States.
概括
虹膜素缺乏会在出血性损伤期间恶化心脏功能和炎症. 补充虹膜素可以拯救这些负面影响,突出其在出血和复苏中的关键保护作用.
科学领域:
- 代谢调节 代谢调节 代谢调节
- 心血管生理学心血管生理学
- 伤害反应的反应
背景情况:
- 虹膜素调节新陈代谢和组织存活.
- 虹膜素在出血性损伤中的作用尚不清楚.
研究的目的:
- 确定虹膜素在出血和复苏 (H/R) 中的功能.
- 调查伊丽素缺乏是否会影响H/R结果.
主要方法:
- 在小鼠H/R模型中使用伊丽素淘汰小鼠和药理方法.
- 诱导出血,平均动脉血压为35-45mmHg,持续60分钟,随后进行2小时的复苏.
- 评估心脏功能,血清细胞因子,炎症,亡和氧化酸化.
主要成果:
- 虹膜素缺乏在H/R期间加剧了心脏功能障碍,增加了炎症 (互白素-6,炎症细胞透),亡 (caspase-3),减少了氧化酸化和ATPase活性.
- 灌注伊丽素挽救了伊丽素删除对H/R结果的有害影响.
- 删除虹会使H/R损伤恶化,而虹的使用会减轻损伤.
结论:
- 虹膜在调节对出血和复苏的反应中起着至关重要的作用.
- 虹膜素表现出对H/R诱导的心脏抑郁和炎症的保护作用.
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