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环境毒素暴露与脆弱性之间的关联:使用NHANES 2013-2016全暴露组方法
Kang Luo1, Liang Duan1, Hongyan He1
1Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Ecotoxicology and environmental safety
|October 15, 2025
概括
这项研究将多种环境毒素,包括尼古丁等价物,和,与美国成年人的脆弱性联系起来. 系统性炎症部分调解了这些关联,突出了健康衰老干预措施的潜在目标.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 老年学是指老年学的学科.
背景情况:
- 越来越多的证据表明,环境化学物质的暴露可能会导致脆弱.
- 大多数先前的研究都检查了单一化学物质的暴露,限制了对组合效应的理解.
- 系统性炎症是将环境毒素与脆弱性联系起来的潜在机制.
研究的目的:
- 系统地评估多种环境毒素暴露和脆弱性之间的关联.
- 研究系统性炎症在这些关系中的调解作用.
- 确定导致美国成年人口脆弱的关键环境毒素.
主要方法:
- 分析了2013-2016年国家健康和营养检查调查 (NHANES) 2354名参与者的数据.
- 将61种环境毒素分为10个暴露组的分类.
- 应用暴露范围的关联研究 (ExWAS),删除/替换/添加 (DSA) 和贝叶斯内核机器回归 (BKMR) 模型.
- 调解分析,以评估系统性炎症的作用.
主要成果:
- 在27.9%的参与者中发现了虚弱.
- 埃克斯瓦斯和DSA确定了总尼古丁等效-2,,,锡和N-乙-S-(2-碳氧乙烯) -L-氨酸与脆弱性有显著关联.
- BKMR证实了这些关键暴露和脆弱性之间的正相关性.
- 系统性炎症介导了2.5-14.6%的观察到的关联.
结论:
- 这项研究是第一个全面报告多种环境毒素与美国成年人的脆弱性之间的联系的研究.
- 特定的环境毒素与脆弱性风险的增加有关.
- 系统性炎症起到部分调解作用,这表明它是减轻与环境暴露相关的脆弱风险的潜在治疗目标.
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