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与瘤相关的巨细胞重编程的代谢调节

Hao Fan¹, Dongxiao Lu², Xianyong Yin²

¹Department of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, China; Department of Neurosurgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, 250014, China; Shandong Engineering Research Center of Precision Diagnosis and Treatment Technology for Neuro-oncology, Jinan, 250014, China; Laboratory of Basic and Translational Neuromedicine, The First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, China; Shandong Institute of Brain Science and Brain-inspired Research, Jinan, 250117, China.

Molecular immunology

|October 15, 2025

概括

与瘤相关的巨细胞 (TAMs) 重新编程其新陈代谢,以创建一种免疫抑制性瘤微环境 (TME). 了解TAM代谢重编程为癌症治疗提供了新的目标.

科学领域:

免疫学免疫学免疫学
癌症生物学癌症生物学
代谢过程中的代谢.

背景情况:

瘤相关巨细胞 (TAMs) 是瘤微环境 (TME) 中的关键免疫细胞.
TAMs具有表型可塑性,在促炎 (M1) 和抗炎 (M2) 状态之间转移.
随着瘤的生长,TME变得越来越免疫抑制,由TAMs驱动.

研究的目的:

审查TAMs的代谢重编程.
探索TAM如何保持其免疫抑制表型.
为了确定癌症治疗的潜在代谢标.

主要方法:

文献综述专注于TAM代谢的研究.
对参与TAM功能的代谢途径的分析.
对表型可塑性和M1/M2极化进行讨论.

主要成果:

在葡萄糖,脂质和氨基酸路径中,TAMs经历了显著的代谢重编程.
这种重编程驱动了免疫抑制性TAM表型的建立,通常类似于M2巨细胞.
代谢适应对于TAMs促进瘤生长和转移至关重要.

结论:

代谢重编程是TAM免疫抑制功能的核心.
准TAM代谢途径为癌症治疗提供了一个有希望的策略.
对TAM代谢的进一步研究可能会导致新的治疗干预措施.

关键词:

代谢重编程是一种代谢重编程.瘤微环境是一个微环境.与瘤相关的巨细胞.

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