肠道微生物群的生物标志物使得在患有并发症的儿童中功能性便秘亚型的分层营养方法成为可能
Congfu Huang1, Chunyan Wang2, Bin Wu1
1Department of Pediatrics, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College), Shenzhen, China.
Nutrition (Burbank, Los Angeles County, Calif.)
|October 15, 2025
概括
这项研究揭示了儿科功能性便秘 (FC) 与并发症的明显肠道微生物群 (GM) 变化. 提出了一个新的转基因导向营养框架,用于针对性干预儿童的FC和相关条件.
科学领域:
- 微生物学 微生物学
- 儿科 儿科 儿科
- 营养科学 营养科学
背景情况:
- 儿童的功能性便秘 (FC) 当与过敏性鼻炎 (AR),食物过敏 (FA) 或神经发育障碍 (DD) 同时出现时,会带来独特的肠道微生物群 (GM) 挑战.
- 患有这些并发症的儿科FC患者的特定营养需求仍然在很大程度上没有得到解决.
研究的目的:
- 调查与特定并发症相关的儿科FC亚型的肠道微生物群变化.
- 探索这些儿科群体的饮食和肠道微生物群之间的关系.
- 根据儿童FC的转基因配置文件,制定个性化的营养策略.
主要方法:
- 一项涉及127名6岁以下儿童的横截面研究,分为孤立的FC,FC+AR,FC+FA,FC+DD和健康的对照.
- 使用16S rRNA测序分析便样本以识别肠道微生物群生物标志物.
- 通过24小时回忆和食物频率问卷来评估饮食摄入量,以确定饮食与微生物的相互作用.
主要成果:
- 所有功能性便秘 (FC) 亚型都显示出减少了短链脂肪酸 (SCFA) 生产细菌的水平.
- 针对每一种并发性疾病确定了特定的转基因特征:FC+FA显示出菌的增加,FC+DD增加了蓝性菌的正常多样性,FC+AR显示出下降的亚多极粒体与改变的免疫信号.
- 饮食模式,如避免动物蛋白质,与FC亚型的特定微生物变化相关.
结论:
- 建议在儿科功能性便秘 (FC) 中进行分层营养干预,以肠道微生物群为导向的新框架.
- 建议包括SCFA生产剂和维生素A用于炎症亚型 (FC+AR/FC+FA),肠-大脑轴调节器用于神经发育性FC (FC+DD),以及纤维优化用于孤立的FC.
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