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Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
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在瘤微环境中重新编程自然杀手细胞:挑战和治疗机会

Wenxue Ma1, Sheldon Morris2, Catriona Jamieson2

  • 1Sanford Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.

Cytokine & growth factor reviews
|October 15, 2025
PubMed
概括

自然杀手 (NK) 细胞在癌症免疫中表现出双重作用. 虽然它们具有强大的细胞毒性作用,但它们也可以成为瘤微环境中的抑制性瘤相关NK细胞 (TANK),从而阻碍免疫治疗.

关键词:
癌症免疫疗法癌症免疫疗法细胞因子信号传递功能性可塑性 功能性可塑性免疫检查点封锁 (ICB)自然杀手 (NK) 细胞瘤微环境 (TME) 是指瘤的微环境.

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