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维生素C在灵长类动物的卵巢上传递了老年保护作用

Ying Jing¹, Huifen Lu¹, Jingyi Li²

¹Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Beijing Key Laboratory of Environment and Aging, Xuanwu Hospital Capital Medical University, Beijing 100053, China.

|October 15, 2025

概括

口服维生素C对子的卵巢衰老有保护作用. 这种抗氧化剂减少了关键的衰老标志物和生物年龄,为人类的卵巢衰老提供了潜在的干预措施.

科学领域:

生殖生物学生殖生物学
老年学是一门学科.
营养科学营养科学

背景情况:

卵巢衰老显著影响女性生殖健康和生活质量.
缓解灵长类卵巢衰老的干预措施尚未得到充分探索.
了解卵巢衰老的生物机制对于开发有效的治疗方法至关重要.

研究的目的:

为了研究单一药物剂维生素C对灵长类动物卵巢衰老的老年保护作用.
评估维生素C对卵巢组织中关键衰老生物标志物的影响.
探索参与维生素C在卵巢中的潜在抗衰老作用的分子途径.

主要方法:

一项为期3.3年的研究,涉及向子口服维生素C.
评估卵巢衰老生物标志物,包括氧化应激和卵泡数量.
应用单细胞转录原子钟来确定卵细胞和体细胞的生物年龄.
分析NRF2通路在细胞衰老和炎症中的作用.

主要成果:

口服维生素C在灵长类动物模型中表现出显著的抗卵巢衰老的生理保护作用.
维生素C降低了关键的衰老生物标志物,如氧化应激和卵泡枯竭.
卵细胞的生物年龄减少了1.35年,体细胞的生物年龄减少了5.66年.
确定NRF2通路是关键的调解者,缓解卵巢细胞衰老和炎症.

结论:

维生素C对灵长类动物的卵巢衰老具有强大的老年保护性.
这些发现表明,维生素C可以逆转卵巢细胞中的生物衰老标志物.
这项研究为开发针对人类卵巢衰老的基于维生素C的干预措施提供了基础.

关键词:

这就是NRF2的NRF2.老化的老化衰老的老化时钟的老化时间抗氧化剂是一种抗氧化剂.这是一种炎症炎症炎症炎症.卵巢卵巢是一个卵巢.氧化应激是一种氧化应激.灵长类的灵长类动物.衰老是一种老化.维生素C是维生素C的重要组成部分.

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