禁食改善了健康的雌性比格尔犬中口服中mitragynine的生物可用性

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Abigail Ortiz¹, Elizabeth A Maxwell¹, Michelle Kuntz²

¹Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL.

American journal of veterinary research

|October 15, 2025

概括

与被养的狗相比,给禁食的狗注入封装的kratom提取物导致了更快的吸收和更高的mitragynine暴露. 这表明,当空腹服用kratom时,药理学潜力更大.

科学领域:

药理学和毒理学药理学和毒理学
药物代谢和药理动力学

背景情况:

克拉 (Mitragyna speciosa) 是一种原产于东南亚的热带树.
它的叶子含有精神活性类化合物,主要是米特拉基宁和7-氧米特拉基宁.
了解克拉的药理动力学特征对于评估其安全性和有效性至关重要.

研究的目的:

在健康的雌性比格尔犬中评估封装 kratom 提取物的药理动力学特征.
为了评估封装 kratom 提取物的安全性.
为了比较在给食者和禁食者服用时的药理动力学特征.

主要方法:

对8只健康的雌性比格尔进行了24小时的药理动力学研究,分为食和禁食组.
狗接受了一个封装的kratom提取物 (8毫克,45%的米特拉基尼).
使用UPLC-MS-MS测量了米特拉金因和代谢物的血度,并进行了包括临床监测和实验室分析在内的安全性评估.

主要成果:

与养狗 (25.6 ng/mL在7.5小时) 相比,禁食狗 (55.2 ng/mL在1.3小时) 的密拉基宁血峰值显著更高,并且更早发生.
食小组中,米特拉基宁的相对生物利用率降低了30%.
封装的 kratom 提取物耐受性良好,没有观察到任何不良影响.

结论:

封装的 kratom 提取物被快速吸收,并导致更大的系统性暴露的mitragynine 当给予禁食对象.
这些发现表明,当空腹服用kratom时,它可能会增强其药理学效果.

关键词:

米特拉基纳特异性植物类化合物是一种类化合物.狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗克拉托姆 (Kratom) 是一种药物动力学药物动力学

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