音乐增强了脂质纳米粒子向大脑输送和大脑细胞中的mRNA转染
Patricia Mora-Raimundo1, Alon Gilon2, Haim Kadosh3
1The Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion - Israel Institute of Technology, Haifa 3200003, Israel.
概括
低频声音增强了脂质纳米颗粒 (LNP) 的脑部传递,用于神经治疗. 这种非侵入性方法显著增加神经元和脑组织中的基因表达,为精准医学提供了一种新的方法.
科学领域:
- 神经科学是一个神经科学.
- 生物技术是生物技术.
- 药理学 药理学是指药理学的学科.
背景情况:
- 向大脑输送治疗药物对于治疗神经系统疾病至关重要.
- 脂质纳米颗粒 (LNP) 显示出药物输送的前景,但在脑透方面面临挑战.
- 提高LNP向神经元的传递对于有效的神经治疗至关重要.
研究的目的:
- 调查音乐和可听的声音波的潜力,以增强通过血脑屏障的LNP传递.
- 探索不同声音频率对神经元纳米粒子吸收的影响.
- 评估声音增强LNP输送的体内疗效和安全性.
主要方法:
- 初级皮质神经元和小鼠被暴露在各种声音频率 (低,中,高) 和复杂的声带中.
- 静脉注射mRNA-LNP在体内使用,有或没有低频声音暴露.
- 使用质谱和功能性MRI分析蛋白质表达,免疫反应和大脑活动.
主要成果:
- 低频声音 (10-250赫兹) 在神经元培养中显著增加了LNP吸收和基因表达 (10倍).
- 在体内,低频声音暴露导致小鼠大脑的mRNA表达更高,特别是在听觉处理区域.
- 声音刺激调节了参与细胞吸收和免疫反应的血蛋白,减少了中性粒细胞.
结论:
- 可听到的低频声音是一种非侵入性方法,可以增强LNP传递和大脑中的基因表达.
- 这种方法对精准医学有潜力,使得有针对性的神经治疗成为可能.
- 基于声音的神经刺激可能为管理神经系统疾病提供了一种新的策略.
相关概念视频
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