血芽细胞作为免疫调节器或放大器在COVID-19中的双重作用
Emmanuel Ledoult1, Thomas Guerrier2, Sylvain Dubucquoi3
1Univ. Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, Lille, France; CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre de Référence des Maladies Auto-Immunes et Auto-Inflammatoires Rares du Nord, Nord-Ouest, Méditerranée et Guadeloupe (CeRAINOM), Lille, France.
Clinical immunology (Orlando, Fla.)
|October 15, 2025
概括
血芽细胞 (PB) 在COVID-19期间扩大,在轻度病例中起到免疫调节作用,但在严重疾病中放大炎症,增加死亡风险. 针对BAFF可能有助于管理PB驱动的免疫失调.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 病理生理学 病理生理学
背景情况:
- COVID-19与显著的血细胞 (PB) 扩张有关.
- 这些扩展PBs在疾病发病过程中的确切功能作用尚未完全理解.
研究的目的:
- 为了研究COVID-19患者血细胞的动态和功能特征.
- 确定PB轨迹与疾病严重程度或死亡率之间的关联.
主要方法:
- 在前性和后性COVID-19队列中进行B细胞免疫类型和多重细胞因子分析.
- 从严重和不严重的病例中对PB的转录组分析.
- 模拟PB轨迹和与临床结果的相关性.
主要成果:
- 在COVID-19早期的PB扩张与疾病严重程度和炎症相关.
- 确定了两个不同的PB轨迹:暂时和持久/放大.
- 持续的PB扩张与30天死亡率增加六倍有关.
- 严重的病例显示PB对纯素代谢基因的上调,而非严重的病例显示干扰素和MHC-II程序.
- BAFF水平与严重程度相关,这表明在PB维持中发挥了作用.
结论:
- 血芽细胞在COVID-19中表现出功能双重性,在不严重的病例中充当免疫调节剂,在严重的疾病中充当炎症放大剂.
- 持续的PB扩张是增加死亡率的预测因素.
- 在严重的COVID-19中,BAFF是管理PB驱动的免疫失调的潜在治疗目标.
相关概念视频
B Cell Activation and Differentiation
16.0K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
16.0K
Humoral Immune Responses
83.3K
Overview
83.3K
Immune Response Against Viral Pathogens
1.7K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.7K
Cell-mediated Immune Responses
83.5K
Overview
83.5K
T Cell Types and Functions
2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K
T Cell Activation and Clonal Selection
14.7K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
14.7K


