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血清维生素B12水平与印度儿童潜在B12-产生肠道微生物的丰富性之间的反向关联
Nisha Chandel1, Priyansh Patel1, Pramod R Somvanshi2
1Department of Systems and Computational Biology, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana, India.
The Journal of nutrition
|October 15, 2025
概括
肠道微生物群可以通过增加产生维生素B12的细菌来适应维生素B12缺乏. 这项研究在缺乏维生素的儿童中发现了更多的B12生产者,这表明微生物群对低维生素水平的潜在反应.
科学领域:
- 人类肠道微生物组研究研究
- 营养科学 营养科学
- 微生物的新陈代谢
背景情况:
- 人的肠道微生物组产生必需的微量营养素,包括B族维生素.
- 之前的研究已经在全球范围内确定了肠道微生物群中的B维生素生产者.
- 肠道微生物在宿主维生素B12水平中的作用是一个正在进行的研究领域.
研究的目的:
- 调查B维生素生产者的存在与血清B维生素水平之间的关联.
- 检查维生素B12作为这种协会的具体案例研究.
- 为了比较缺乏维生素B12的儿童与没有缺乏维生素B12的儿童的肠道微生物组合.
主要方法:
- 从印度的维生素B12缺乏和没有缺乏的儿童收集了便样本.
- 整个元基因组DNA被测序用于分类学分析和多样性分析.
- 确定了潜在的维生素B12生产者与血清B12水平的患病率,丰度和相关性.
主要成果:
- 维生素B12缺乏的儿童显示样本间微生物群多样性明显较低.
- 缺乏维生素B12的组中,携带维生素B12载体的细菌和已知的维生素B12生产者的数量更高.
- 潜在的B12生产者在缺乏的儿童中更为普遍和丰富,与血清B12水平负相关.
结论:
- 在缺乏维生素B12的个体中,维生素B12生产者的较高丰富程度表明肠道微生物群的潜在适应机制.
- 微生物组可以选择性地促进B12生产者满足社区维生素需求.
- 需要进一步的研究来确定B12生产者和缺乏之间的因果关系.
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