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一个双层乳液凝稳定由酸乳清蛋白分离物和奇托桑提供黄素:特征,稳定性和消化特性

Fei-Yue Xu¹, Jin-Lin Cai², Bo-Ru Chen¹

¹Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan, 528225, China; College of Food Science and Engineering, Foshan University, Foshan, 528225, China.

International journal of biological macromolecules

|October 15, 2025

概括

这项研究创建了一个新型的双层乳液凝,使用化乳清蛋白分离物 (SWPI) 和奇托 (CS) 来增强黄素的输送. 凝提供了更好的稳定性,氧化保护和受控的消化,展示了其对生物活性化合物封装的潜力.

科学领域:

食品科学与技术食品科学与技术
生物材料科学生物材料科学
药物输送系统药物输送系统

背景情况:

乳清蛋白分离物 (WPI) 和奇托 (CS) 是具有食品和生物医学应用潜力的生物相容聚合物.
开发像黄素这样的生物活性化合物的稳定乳液系统对于它们的有效性至关重要.
了解复杂的传递系统的结构和消化特性对于优化其性能至关重要.

研究的目的:

开发和描述一种新型的双层乳液凝系统,使用化乳清蛋白分离物 (SWPI) 和奇托 (CS).
为了研究SWPI-CS (HCS) 乳液凝的结构,稳定性和消化性能.
评估HCS系统作为黄素的输送平台,评估其氧化保护和生物可访问性.

主要方法:

在SWPI和CS之间复杂的形成,用于结合分析的分子对接.
在不同的pH值和离子强度下对乳液稳定性的表征.
光成像可视化三层结构.
黄素封装和氧化稳定性和体外生物可访问性的评估.
风学测量以确定凝的特性.
在体外消化研究评估胃抵抗和肠道释放.

主要成果:

分子对接表明SWPI和CS之间的结合亲和力在化后得到增强.
在pH 4和160 mM NaCl.Cl下观察到HCS乳液的最佳稳定性.
光成像证实了一种三层结构,其中有一个外部的CS层和内部的SWPI层.
封装的黄素显示在24小时后90%的保留率和37.5%的生物可访问性.
凝发生在体积分数≥0.4时,NaCl加强了网络.
该HCS系统证明了胃抵抗性和控制的自由脂肪酸的肠道释放.

结论:

双层HCS乳液凝提供了一个稳定有效的系统,用于封装和输送像黄素这样的生物活性化合物.
SWPI和CS之间的协同作用增强了结构完整性和受控释放特性.
这种HCS系统为提高敏感生物分子的稳定性和生物可用性提供了一个有希望的平台.

关键词:

双层乳液是双层乳液.生物可访问性生物可访问性基托桑是一种酸盐.库尔库明是一种黄素.糖化乳清蛋白分离剂糖化乳清蛋白分离剂

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