基于共识的疾病定义,用于免疫检查点抑制剂的内分泌免疫相关不良事件
Ling Zhu1, Yee-Ming M Cheung2, Cherie Chiang3
1Department of Endocrinology, Singapore General Hospital, Singapore.
Journal for immunotherapy of cancer
|October 15, 2025
概括
这项研究开发了基于共识的陈述,用于诊断与免疫相关的内分泌不良事件 (E-irAEs) 在癌症患者治疗免疫检查点抑制剂 (ICI). 这些标准化指南旨在改善准确及及时诊断和管理E-irAEs.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 是关键的癌症疗法.
- 内分泌免疫相关的不良事件 (E-irAEs) 是常见的,并且难以诊断.
- 缺乏标准化阻碍了及时的E-irAE评估和管理.
研究的目的:
- 为E-irAEs建立基于共识的疾病定义.
- 开发标准化方法来诊断和管理特定的E-irAEs.
- 为改善患有E-irAEs的患者的临床护理.
主要方法:
- 使用了经过修改的Delphi过程 (RAND/UCLA适当性方法).
- 一个由25名专家组成的专家小组 (内分泌学家,瘤学家等). 参与了,参加了.
- 两轮调查和专家会议完善了共识陈述.
主要成果:
- 在所有41个关于E-irAE定义和管理的声明中达成共识.
- 建立了对E-irAEs的标准化命名法和评估标准.
- 针对甲状腺,垂体/上腺和糖尿病 E-irAEs 开发了严重性分级表.
结论:
- 开发的陈述解决了E-irAE诊断和管理中的关键缺口.
- 这些共识指南为标准化E-irAE护理提供了基础.
- 预计改善标准化将提高ICI治疗患者的治疗结果.
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