瘦肉 MASLD 的长期预后:来自三个基于人口的潜在队列的证据
Zhenyu Huo1, Yijun Chen1, Yating Huang2
1Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing, China.
Gut
|October 15, 2025
概括
患有代谢功能障碍相关的脂肪性肝病 (MASLD) 的瘦肉患者面临更高的肝脏问题和死亡风险,尽管癌症的发病率相似. 然而,与非瘦身的MASLD个体相比,他们患心血管疾病的风险较低.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 流行病学 流行病学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 增加了肝脏和非肝脏并发症的风险.
- 瘦肉MASLD的预后仍然存在争议,需要进一步调查.
研究的目的:
- 为了比较瘦身与非瘦身MASLD患者的长期预后.
- 分析西方和亚洲人群的结果.
主要方法:
- 一项前性多队列研究,涉及来自英国生物银行,开鲁安和中国Kadoorie生物银行的18万多名MASLD患者.
- 瘦身MASLD定义为BMI<23 kg/m2 (Kailuan, CKB) 或<25 kg/m2 (UKB). 瘦身MASLD的定义为BMI<23 kg/m2 (Kailuan, CKB) 或<25 kg/m2 (UKB).
- 主要终点包括肝脏相关事件,全因死亡率,肝脏相关死亡率,心血管疾病 (CVD) 死亡率,心血管疾病,肝细胞癌 (HCC) 和肝癌.
主要成果:
- 瘦身MASLD患者表现出与肝脏相关事件 (HR=2.14),所有原因死亡率 (HR=1.26),与肝脏相关死亡率 (HR=2.31) 和心血管疾病死亡率 (HR=1.22) 的风险明显更高.
- 相反,瘦肉MASLD与可比的HCC风险 (HR=1.76) 和额外肝癌风险 (HR=1.14) 有关.
- 一个值得注意的发现是,与非瘦患者相比,瘦肌MASLD患者心血管疾病风险降低 (HR=0.89).
结论:
- 瘦身MASLD患者的肝脏结果较差,全因死亡率增加.
- 瘦和非瘦MASLD组之间,HCC和肝癌的风险是相似的.
- 瘦MASLD与心血管疾病风险降低有悖论的关联.
更多相关视频
09:57Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
Published on: March 5, 2018
30.4K
06:52Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases
Published on: September 29, 2014
54.5K
相关概念视频
02:20Longitudinal Research
13.1K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.1K
01:26Longitudinal Studies
477
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
477