与喉相关的IgG4相关疾病:一个病例报告和文献综述
Mingyuan Ouyang1, Yijun Dong1, Hanwen Zhu2
1Department of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Journal of voice : official journal of the Voice Foundation
|October 15, 2025
概括
与IgG4相关的疾病 (IgG4-RD) 很少影响喉,经常模仿瘤. 早期诊断和多学科护理对于管理这种罕见的上呼吸道阻塞至关重要.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 与IgG4相关的疾病 (IgG4-RD) 是一种罕见的系统性纤维炎症疾病.
- 喉参与IgG4-RD异常罕见,并且由于非特异性症状和类似瘤的呈现,难以诊断.
研究的目的:
- 报告一个独特的喉IgG4相关疾病病例.
- 突出这一罕见疾病的诊断挑战和管理策略.
主要方法:
- 一个60岁妇女患有渐进性呼吸障碍的案例研究.
- 诊断工作包括成像,多次活检和血清IgG4水平评估.
- 治疗包括分阶段的二氧化碳激光手术和全身性皮质糖类药物.
主要成果:
- 该患者在多次活检后被诊断出喉IgG4-RD.
- 图像检测显示,在口腔桃体,皮下组织,肋骨和淋巴结中还有其他无症状病变.
- 组织学证实了密集的IgG4阳性血细胞透;血清IgG4水平升高.
- 患者对手术干预和葡萄糖皮质激素治疗产生了积极的反应.
结论:
- 喉IgG4-RD是一种罕见的对上呼吸道阻塞的差异诊断.
- 早期的多学科评估和及时干预对于有利的结果至关重要.
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