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在VTA的生命早期应激激活细胞中,持久的开放色素状态

Rebekah L Rashford1, Michael DeBerardine1, Shu Dan1

  • 1Princeton Neuroscience Institute, Princeton University, Princeton, NJ, 08544, USA.

Scientific reports
|October 15, 2025
PubMed
概括

生命早期的压力会在大脑的腹膜区域 (VTA) 中产生持久的表观遗传变化. 这种分子记忆为应激激活的细胞提供了原始信息,从而增加了对压力和精神疾病的终身脆弱性.

关键词:
ATAC-seqq 的使用情况.活动依赖性遗传标记 (TRAP)早期生活中的压力.表观遗传原始化 (epigenetic priming) 是一种表观遗传原始化.表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.腹部顶部区域的区域.

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