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Updated: Jan 15, 2026

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
07:02

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

Published on: February 11, 2019

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长期释放口服悬浮剂和长期释放片的甲基胺粉末与甲基胺即时释放片的比较生物可用性:第一阶段,单剂量,随机,健康成年人的交叉研究

Josep Antoni Ramos-Quiroga1,2,3,4, Marta Forcadell Ferré5, Alex Schneider-Pérez6

  • 1Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, Spain.

Clinical drug investigation
|October 15, 2025
PubMed
概括

新的延长释放 (PR) 甲基酸盐口服悬浮剂和可片配方提供与即时释放片的生物等效暴露. 这些新选择为ADHD治疗提供了可容忍的替代方案,解决了对灵活剂量和吞困难的未满足需求.

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Utilizing an Orally Dissolving Strip for Pharmacological and Toxicological Studies: A Simple and Humane Alternative to Oral Gavage for Animals04:28

Utilizing an Orally Dissolving Strip for Pharmacological and Toxicological Studies: A Simple and Humane Alternative to Oral Gavage for Animals

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Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
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Bioequivalence studies: Biowaivers

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Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...
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