心脏代谢风险负担与阿司匹林使用者胃肠道出血的关联
Yajing Wei1, Jiamin Yan1, Ziting Gao1
1Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, No 1, Xue Yuan Road, University Town, Fuzhou, Fujian, 350108, China.
BMC gastroenterology
|October 15, 2025
概括
较高的心脏代谢风险负担显著增加了阿司匹林使用者的胃肠道 (GI) 出血风险. 需要针对这些患者量身定制的预防策略.
科学领域:
- 心脏病学 心脏病学
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 阿司匹林经常被处方用于缺血性心血管疾病,通常与心脏代谢障碍同时发生.
- 在阿司匹林使用者中,心脏代谢风险和胃肠道 (GI) 出血之间的关系需要研究.
研究的目的:
- 评估心脏代谢风险负担对服用阿司匹林的人第一次胃肠道出血的发生率的影响.
- 量化心脏代谢风险因素增加与胃肠道出血风险之间的关联.
主要方法:
- 一项使用英国生物库数据的队列研究,包括患有缺血性心血管疾病和阿司匹林处方的患者.
- 心脏代谢风险负担是通过总结肥胖,糖尿病,失脂症和高血压的存在来计算的.
- 考克斯的比例危险模型被用来确定GI出血的危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 平均随访时间为13.4年,胃肠道出血的发生率随着心脏代谢风险因素 (0-4) 的增加而上升,从每1000人年4.53到9.64.
- 与没有危险因素的患者相比,调整后的胃肠道出血的HR随着负担的增加 (1.09至1.95),糖尿病和高血压表现出明显的影响 (HR=1.24).
- 这种关联在以前有胃肠道问题的人,年轻人和男性中更为强烈.
结论:
- 较高的心脏代谢风险负担与阿司匹林使用者的胃肠道出血风险增加有显著关联.
- 这些发现强调了需要个性化消化道出血预防策略在阿司匹林使用者,考虑到他们的心脏代谢风险概况.
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