血清标记物和胃癌:一个总体审查
Afra Darvishi1,2, Amirhosein Dadashzadeh Asl1, Pouya Golshaniniya1,3
1Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
BMC gastroenterology
|October 15, 2025
概括
本总体综述确定了用于早期检测胃癌 (GC) 的关键血清生物标志物. 较低的SOD活性,素和,以及dickkopf-1和pepsinogen,显示出用于GC诊断和风险预测的潜力.
科学领域:
- 在瘤学瘤学.
- 生物标志物发现发现
- 胃肠病学 胃肠病学
背景情况:
- 胃癌 (GC) 构成了全球重大健康负担.
- 早期发现GC对于改善患者的治疗结果和降低死亡率至关重要.
- 血清生物标志物为非侵入性GC诊断和风险评估提供了一个有希望的途径.
研究的目的:
- 对用于胃癌检测和风险预测的血清标记物进行系统性审查进行总体审查.
- 在GC的背景下,综合各种血清生物标志物的实用性证据.
- 为了确定有前途的血清生物标志物用于早期GC诊断和风险分层.
主要方法:
- 在PubMed,Scopus和Web of Science数据库进行系统搜索,截至2023年8月31日.
- 包括英语系统审查,评估血清标志物对GC存在或风险预测.
- 使用Joanna Briggs Institute (JBI) 批判性评估工具对包含的评论进行质量评估.
主要成果:
- 从1441个记录中选择了七个系统审查.
- 研究的血清标志物包括SOD活性,,阿迪波内克丁,dickkopf-1,pepsinogens和自身抗体.
- 较低的SOD活性,循环中的和与GC有关;dickkopf-1和pepsinogen也显示出潜在的作用.
结论:
- 已识别的血清生物标志物显示出有助于GC诊断和风险预测的潜力.
- 需要进一步的大规模,精心设计的研究来验证这些发现并确定临床效用.
- 异质性和潜在的出版偏见需要谨慎的解释和进一步的研究.
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