三种不同的食补充剂干预措施的抗炎作用
Amrita Vijay1, Liz Simpson2, Melanie Tooley2
1NIHR Nottingham Biomedical Research Centre and Academic Unit of Injury, Recovery and Inflammation Science, School of Medicine, University of Nottingham, Nottingham, UK. amrita.vijay@nottingham.ac.uk.
Journal of translational medicine
|October 15, 2025
概括
饮食干预措施包括共生菌,欧米茄-3和胰岛素纤维有效降低了全身炎症. 协生性干预显示出最广泛和最强大的抗炎作用,影响与免疫和代谢健康相关的蛋白质.
科学领域:
- 营养免疫学 营养免疫学
- 微生物组研究 微生物组研究
- 代谢健康 代谢健康
背景情况:
- 饮食显著影响炎症,需要确定特定的抗炎饮食成分.
- 这项研究研究了益生菌纤维 (胰岛素),omega-3脂肪酸和同生菌 (发酵 + 益生菌纤维) 在六周内对炎症标志物的影响.
研究的目的:
- 评估单一来源的益生菌纤维,欧米茄-3和同生菌补充剂对广泛的血清炎症标志物的影响.
- 为了比较这些不同的饮食干预措施的抗炎疗效.
主要方法:
- 一项为期6周的干预研究,涉及四组:共生,欧米茄-3,胰岛素纤维和对照组.
- 使用Olink 96炎症面板分析血清炎症蛋白质.
- 统计分析包括参数方法,效果大小 (科恩的d) 和FDR对显著性的调整.
主要成果:
- 与对照组相比,所有三种干预措施 (共生,欧米茄-3,胰岛素) 都显著降低了炎症标志物.
- 补充欧米茄-3和胰岛素纤维显著降低了瘤缩因子-α (TNF-α).
- 协生干预导致多个炎症标志物的更广泛和更实质性的减少,包括INTERLEUKIN-6 (IL-6),INTERFERON-GAMMA (IFN-γ),SIRT2,4EBP1,CCL23,CCL25和CCL28. 血清丁酸盐水平升高与协生组IL-6降低相关.
结论:
- 协生菌,欧米茄-3和胰岛素纤维补充剂都有助于减少全身炎症.
- 协生菌表现出最全面和最强的抗炎作用,影响与免疫和代谢功能相关的蛋白质.
- 未来的研究将纳入肠道微生物组分析,以阐明共生介导炎症调节的基础机制.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
635
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
635
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
483
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
483
Inflammatory Bowel Disease IV: Pharmacological Management
496
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
496
Drugs for Treatment of Ulcerative Colitis in IBD
452
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
452
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
429
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
429
Inflammatory Response
15.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.9K


