非侵入性测试与数字病理学之间的关系,用于量化MASLD中的肝纤维化
Xiaodie Wei1, Lixia Qiu1, Xinxin Wang2
1The Third Unit, Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Diagnostics (Basel, Switzerland)
|October 16, 2025
概括
数字病理学和磁共振弹性图 (MRE) 准确地评估了代谢功能障碍相关的脂肪性肝病 (MASLD) 中的肝纤维化. MRE-肝硬度测量与数字病理纤维化量化有很强的相关性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 医疗成像医学成像
- 数字病理学数字病理学
背景情况:
- 评估肝纤维化在与代谢功能障碍相关的脂肪性肝病 (MASLD) 中至关重要.
- 数字病理学提供自动化,定量纤维化测量,提高准确性和减少变化.
- 数字病理学与MASLD纤维化评估的非侵入性测试 (NIT) 之间的关系尚不清楚.
研究的目的:
- 在MASLD患者中探索数字病理学定量纤维化参数与各种非侵入性测试 (NIT) 之间的相关性.
- 评估数字病理学和NIT在评估肝纤维化阶段的诊断性能.
主要方法:
- 一项涉及99名活检证明的MASLD患者的研究.
- 定量纤维化 (Q-纤维化) 用第二波生成/两光子激发光显微镜 (SHG/TPEF) 进行测量.
- 分析了八个NIT和定量纤维化参数 (q-FPs) 之间的相关性.
主要成果:
- Q-纤维化显示出纤维化阶段的良好诊断性能 (AUC 0.924-0.967).
- 磁共振弹性图 (MRE) 显示了NIT中最高的诊断准确度 (AUC 0.781-0.977).
- MRE-肝硬度测量 (MRE-LSM) 显示与q-FPs的相关性最强,受原特性的影响.
结论:
- 在MASLD中,MRE和数字病理学都非常准确地诊断肝纤维化.
- MRE-LSM受到原沉积的程度,位置和模式的显著影响.
- 这为与组织纤维化逆转相关的MRE变化提供了新的见解.
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