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调节性免疫细胞,甲状腺细胞重塑和晚期冠状动脉样硬化中血管衰老之间的关联:试点研究
Irina Kologrivova1, Alexey Dmitriukov1, Natalia Naryzhnaya1
1Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 111A Kievskaya, Tomsk 634012, Russia.
Diagnostics (Basel, Switzerland)
|October 16, 2025
概括
甲状腺功能障碍,标志着免疫细胞组成的改变,伴随着冠状动脉疾病 (CAD) 的进展. 在CAD患者中,血管衰老与肌髓衍生抑制细胞 (MDSCs) 的增加和内皮原生细胞的减少有关.
科学领域:
- 免疫学 免疫学 免疫学
- 心脏病学 心脏病学
- 衰老研究研究 衰老研究
背景情况:
- 冠状动脉疾病 (CAD) 的生物衰老包括冠状动脉样硬化,血管衰老和内皮功能障碍.
- 胸腺在免疫调节中起着至关重要的作用,其功能可能在CAD患者中发生变化.
研究的目的:
- 在患有CAD的患者中,研究衰老表型,调节性免疫细胞和胸腺特征之间的关系.
- 探索甲状腺功能障碍和免疫细胞变化如何与冠状动脉样硬化和血管衰老的严重程度相关.
主要方法:
- 一项涉及CAD患者的比较研究,根据根西尼得分 (动脉样硬化严重程度) 分层.
- 使用成像流动细胞计,ELISA和免疫组织化学分析周围血液和胆髓活检.
- 评估免疫细胞种群,包括T淋巴细胞,NK细胞,MDSC和Treg以及内皮前代细胞.
主要成果:
- 胸腺形态与动脉样硬化严重程度无关,但在具有较高根西尼分数的患者中,细胞组成受损 (CD8+ T和NK细胞增加,CD4+CD8+ T细胞减少).
- 早期髓衍生抑制细胞 (eMDSC) 和CD25低Tregs的低数量与严重动脉样硬化有关.
- 先进的血管衰老与高的eMDSC计数和循环内皮前代细胞减少相关.
结论:
- 甲状腺功能障碍,以改变免疫细胞组成为特征,与CAD进展有关.
- MDSCs和Tregs与CAD进展有关,由减少内皮细胞调节功能加剧.
- 血管衰老是CAD中明显的衰老表型,其特征是eMDSC扩张.
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