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不育和生育患者的阴道微生物组成的差异:一项前性研究
Pei-Chen Chen1,2, Shih-Fen Chen3, Wei-Tung Hung3
1Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan.
Diagnostics (Basel, Switzerland)
|October 16, 2025
概括
阴道失生症,特别是由Prevotella主导的社区状态类型IVA,在不孕妇女中更为常见. 这表明不良的阴道环境会影响生育能力,而螺杆菌的存在表明健康的微生物群.
科学领域:
- 微生物学 微生物学
- 生殖健康 生殖健康
- 遗传学 遗传学 是一个
背景情况:
- 阴道微生物群失生症,以减少Lactobacillus spp.为标志,与女性不孕症有关.
- 社区国家类型 (CST) IV在不孕症方面未得到充分研究.
- 本研究的重点是比较CST IVA和IVB在生育和不育妇女之间.
研究的目的:
- 为了比较受孕和不孕妇女的阴道微生物组合,特别是CST IVA和IVB.
- 研究特定微生物特征与女性不孕症之间的关联.
- 为了确定潜在的微生物生物标志物用于不孕.
主要方法:
- 一项涉及22名女性的前性研究 (15名不育,7名肥沃).
- 在Illumina MiSeq平台上使用16S rRNA基因测序 (V3-V4区域) 分析的阴道样本.
- 使用QIIME 2进行的分类学分类;使用Wilcoxon等级和试验进行的统计分析.
主要成果:
- 不育的妇女表现出较低的相对丰度的乳杆菌 spp. 和 Oscillospira spp. 这种植物.
- 在不育妇女中,CST IV的患病率更高 (29.75%对21.61%).
- 在不育妇女中,CST IVA不成比例地高 (7.0%对0.94%),其特点是Prevotella spp.显著增加. (95.18%与69.77%相对应).
结论:
- 升高的Prevotella spp. 的情况. 在CST IVA内可能会造成不利的阴道环境,可能会损害精子的生存能力并导致不孕.
- 在存在的Oscillospira spp. 的存在. 与生育期妇女的健康阴道微生物群特征有关.
- 对CST IV亚型的进一步研究对于了解女性不孕症至关重要.
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