高压氧气疗法在耐火性周边克罗恩病的管理中
Roy Hajjar1, Katherine A Bews2, Ahmed Amine Alaoui1
1Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN 55904, USA.
Journal of clinical medicine
|October 16, 2025
概括
高压氧气疗法 (HBOT) 为一些耐火性近口克罗恩病 (CD) 患者提供了症状缓解. 然而,长期有效性尚未确定,大多数患者在一年内需要手术.
科学领域:
- 胃肠病学 胃肠病学
- 手术创新 在外科创新.
- 炎症性肠道疾病研究研究
背景情况:
- 克罗恩病 (CD) 是一种全球性炎症性肠病 (IBD),影响胃肠道.
- 在CD中,外周囊病带来了管理方面的挑战,通常需要手术.
- 使用TNF-α抑制剂等生物疗法,但高达80%的围性CD病例是耐火或复发的.
研究的目的:
- 评估高压氧气疗法 (HBOT) 对耐火性近门克罗恩病的疗效.
- 为了评估临床反应和需要手术后HBOT在周围腔CD患者.
- 为了研究HBOT作为复杂的近口CD的潜在治疗选择.
主要方法:
- 梅奥诊所对患有CD且接受HBOT治疗围疾病的患者 (2014-2023) 的回顾性审查.
- 对人口统计数据,病史,并发疗法和便转移状态的分析.
- 对HBOT疗程 (疗程) 和临床结果的审查,包括症状和客观评估.
主要成果:
- 六名患有近口CD的患者 (19-60岁) 接受了10-40次HBOT疗程.
- 四名患者报告症状有所改善,一名患者呈现客观改善.
- 大多数患者 (除了一个外) 经历了疾病进展,并在一年内需要手术.
结论:
- 对于一些患有不耐药的近口CD的患者,HBOT可能会提供暂时的症状缓解.
- 目前的数据表明,HBOT对围性CD的长期疗效有限.
- 需要进行进一步的研究,以确定HBOT在围性CD的管理中的作用和长期影响.
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