新辅助治疗方法对口腔癌的治疗方法
Lyna Siafa1, Aisha Ali2, Paul Kerr1
1Department of Otolaryngology-Head and Neck Surgery, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Journal of clinical medicine
|October 16, 2025
概括
新辅助免疫疗法对口腔状细胞癌 (OSCC) 是有前途的,与化疗相比,提供更好的生存率和更少的副作用. 需要进一步的研究才能将其确立为标准治疗.
科学领域:
- 在瘤学瘤学.
- 头部和部手术 头部和部手术
背景情况:
- 口腔状细胞癌 (OSCC) 患病率很高,尽管手术和化疗辐射的进展,但局部晚期的生存率很低.
- 复发和转移仍然是重大挑战,推动了新的治疗策略的需求,如新辅助疗法.
研究的目的:
- 审查目前的文献和正在进行的关于OSCC新辅助治疗的试验.
- 评估新辅助化疗与局部发达OSCC的免疫治疗的疗效和安全性.
主要方法:
- 通过PubMed搜索和雪球技术识别的临床试验的叙事综述.
- 对21项确定临床试验的分析,重点关注OSCC的新辅助治疗方案.
主要成果:
- 新辅助化疗显示出有利的病理结果,但可变的生存结果.
- 新辅助免疫疗法证明了病理反应和生存结果的改善,严重不良事件的发病率较低.
结论:
- 新辅助疗法是OSCC的一个有希望的方法,但尚未成为标准的护理.
- 与局部先进的OSCC化疗相比,新辅助免疫疗法提供了令人鼓舞的响应率和降低的毒性.
- 进一步的随机试验对于标准化新辅助剂协议和识别反应生物标志物至关重要.
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