口服营养补充剂对营养不良儿童身体组成和骨健康的影响:一项随机对照研究
Anuradha Khadilkar1, Arati Ranade1, Neelambari Bhosale1
1Jehangir Clinical Development Center Pvt. Ltd., Jehangir Hospital Premises, 32, Sassoon Road, Pune 411001, Maharashtra, India.
Journal of clinical medicine
|October 16, 2025
概括
口服营养补充剂与饮食咨询相结合,在营养不良的印度儿童中显著改善了骨矿物质密度和肌肉质量. 这种干预提供了一种有前途的方法来改善早期营养和长期健康结果.
科学领域:
- 儿童营养学 儿童营养学
- 人类成长和发展 人类成长和发展
- 骨健康和新陈代谢
背景情况:
- 口服营养补充剂 (ONS) 支持营养不良儿童的整体生长,但它们对身体组成和骨健康的影响需要进一步研究.
- 早期的营养缺陷可能会对健康产生持久的后果,强调需要有效的干预措施.
- 3至6.9岁的营养风险儿童,特别是那些吃得挑的儿童,需要有针对性的营养支持.
研究的目的:
- 评估ONS与饮食咨询 (DC) 结合对印度儿童的身体组成,骨矿物质密度 (BMD) 和骨矿物质含量 (BMC) 的影响.
- 评估ONS+DC与单独DC相比在改善营养状况和生长参数方面的疗效.
主要方法:
- 一项前性随机对照试验,涉及223名印度3至6.9岁的营养风险儿童.
- 参与者被随机分配,接受ONS+DC或单独DC6个月.
- 在基线和6个月后,使用双能量X射线吸收计 (DXA) 测量身体组成,BMD和BMC.
主要成果:
- 与DC单独组相比,ONS+DC组的BMD (0.023g/cm2对比0.017g/cm2) 和BMC (36.60g对比28.48g) 的改善显著更大 (p < 0.004).
- 在ONS+DC组,瘦肉量显著增加 (926.33g对801.48g;p=0.0401).
- 在ONS+DC组中观察到脂肪质量的数值减少,尽管在统计学上并不显著.
结论:
- 包括ONS和DC在内的有针对性的营养干预措施可以有利地改善营养不良儿童的身体组成和骨健康.
- 这种方法显示出解决早期营养缺陷和促进持久健康益处的潜力.
- 这些发现支持使用ONS+DC作为一种有效的策略,以增强风险儿童群体的生长和发展.
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