怀孕期间吸烟和饮酒:对胎儿和新生儿健康的影响-试点研究
Martina Derme1, Marco Fiore2, Maria Grazia Piccioni1
1Department of Maternal and Child Health and Urology, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
Journal of clinical medicine
|October 16, 2025
概括
怀孕期间吸烟和饮酒与胎儿生长限制有关. 吸烟会增加母亲的氧化压力,但在带血液中可能存在一种保护机制,这需要进一步研究.
科学领域:
- 产科和妇科 产科和妇科
- 围产儿医学 围产儿医学
- 毒理学 毒理学 毒理学
背景情况:
- 怀孕期间饮酒和吸烟存在风险,但机制尚不清楚.
- 氧化应激是一种潜在的途径,将物质使用与不良结果联系起来.
- 了解这些影响对于孕产妇和胎儿的健康至关重要.
研究的目的:
- 调查氧化应激在妊娠并发症中的作用.
- 评估吸烟和酒精对胎儿和新生儿结局的影响.
- 为了评估母体和带血的氧化应激标志物.
主要方法:
- 招募到期的孕妇.
- 通过问卷评估吸烟和饮酒习惯.
- 胎儿生长和母胎循环的超声波评估.
- 分析母亲的头发,血液和带血,检测尼古丁,丁,乙基糖和氧化应激标志物 (FORT/FORD).
主要成果:
- 活跃吸烟者和滥用酒精的人显示新生儿和胎盘体重显著降低.
- 与非吸烟者相比,在吸烟者中观察到更高的母体氧化应激 (FORT) (p < 0.0001).
- 两组之间没有发现带血氧化应激的显著差异 (p = 0.2216).
结论:
- 胎儿生长限制与母亲吸烟和滥用酒精有关.
- 怀孕期间吸烟会增加母亲的氧化压力.
- 胎内保护机制可能会减轻带血中的氧化应激,需要进一步调查.
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