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三糖糖-糖性指数作为中风风险的新型预测指标:全国前性队列研究

Xiaoqi Ye^1,2, Yan Li^1,2, Yebei Liang³

¹Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.

Journal of clinical medicine

|October 16, 2025

概括

新的三糖-葡萄糖-度指数 (TyG-CI) 有效地预测了中风风险. 较高的TyG-CI水平与中风发病率的增加有关,为临床评估提供了一个简单可靠的工具.

科学领域:

心血管流行病学心血管流行病学
代谢综合征研究代谢综合征研究
生物标志物开发生物标志物开发

背景情况:

甘油三糖指数 (TyG) 和度指数 (CI) 是胰岛素抵抗和腹部肥胖的已知标志物.
对Tyg和CI对中风风险的综合影响尚不清楚.
一个新的复合指数,TyG-conicity指数 (TyG-CI) 被开发来评估它们的联合影响.

研究的目的:

调查TyG-conicity指数 (TyG-CI) 与发生性中风风险之间的关联.
将TyG-CI的预测性能与其单个组件 (TyG和CI) 的预测性能进行比较.

主要方法:

一项前性队列研究,涉及8011名45岁以上的参与者,没有先前的中风史.
考克斯比例危险回归模型被用于评估与TyG-CI四分位数相关的中风风险.
限制立方线回归分析了非线性关联,AUC/C指数评估了预测准确性.

主要成果:

在8.36年的时间里,发生了753次中风. 较高的TyG,CI和TyG-CI四分位数与中风风险增加有关 (HR分别为1.36,1.43,1.69).
证实了TyG-CI与中风风险之间的线性关系.
与TyG (0.575) 和CI (0.575) 相比,TyG-CI显示出更高的预测性能 (AUC 0.594).

结论:

提升的TyG-CI显著与发生中风的风险更高有关.
与单独的TyG或CI相比,TyG-CI为中风风险提供了更好的预测价值.
TyG-CI是临床中风风险评估的有希望,简单,可靠和廉价的指标.

关键词:

圆度指数圆度指数预期的队列研究.一次性中风中风中风中风中风三甘油糖糖圆度指数三甘油葡萄糖指数指数

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