长期轴性脊柱关节炎中的尿道炎及其与生物疗法启动的关联:来自REGISPON-3队列的数据
Ana María Sánchez-León1,2,3, María Lourdes Ladehesa-Pineda2,3,4, María Ángeles Puche-Larrubia2,3,4
1Ophthalmology Department, Reina Sofía University Hospital, 14004 Córdoba, Spain.
Journal of clinical medicine
|October 16, 2025
概括
前部急性脑膜炎 (AAU) 影响了超过三分之一的长期轴性脊柱关节炎 (axSpA) 患者,其发病率随着时间的推移而增加. 然而,AAU不会影响生物修饰性抗风湿药物 (bDMARD) 的启动或长期保留.
科学领域:
- 类风湿病学 类风湿病学
- 眼科医生 眼科 眼科
- 临床流行病学临床流行病学
背景情况:
- 轴性脊椎关节炎 (axSpA) 是一种慢性炎症性疾病.
- 前部急性脑膜炎 (AAU) 是 axSpA.的常见的关节外表现.
- 了解AAU发生率及其对治疗的影响对于患者管理至关重要.
研究的目的:
- 确定长期 axSpA.患者中 AAU 的发病率.
- 确定与AAU发展相关的人口和临床因素.
- 评估AAU对生物修饰性抗风湿药物 (bDMARD) 启动和保留的影响.
主要方法:
- 一项采用西班牙SpA注册表 (REGISPONSER) 和其后续研究 (REGISPON-3) 的数据进行的两次时间点队列研究.
- 分析包括299名患有长期axSpA的患者,在17年后重新评估.
- 使用Kaplan-Meier和Cox比例危险模型来评估AAU发生率,预测因素和治疗结果.
主要成果:
- 33.4%的患者至少经历过一次AAU事件,发生率为每100人年1.15人.
- 女性性别和基线肠炎独立地与AAU风险增加有关.
- AAU没有显著影响bDMARD的启动或长期保留,治疗持久率相似.
结论:
- 在长期 axSpA 患者中,AAU 的发生率随着时间的推移而增加.
- 尽管AAU的发生频率很高,但在临床实践中,AAU似乎不会阻碍开始或长期使用bDMARDs.
- 进一步的研究可能会探索axSpA患者的AAU的特定管理策略.
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