通过离子凝用于药物输送的基托桑微粒的开发和表征
Zahra Rajabimashhadi1, Annalia Masi1, Sonia Bagheri1
1Department of Innovation Engineering, University of Salento, 73100 Lecce, Italy.
Polymers
|October 16, 2025
概括
这项研究详细介绍了使用离子凝用于药物输送的奇托桑微粒的制造. 这些颗粒具有可调节的特性和受控释放,具有局部药物递送和组织再生的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 纳米技术 纳米技术
背景情况:
- 酸盐微粒由于其生物相容性和生物降解性,对药物输送有希望.
- 离子凝为微粒制造提供了一种温和可控的方法.
- 了解配方对物理化学性质的影响对于优化药物输送应用至关重要.
研究的目的:
- 通过离子凝来制备和表征奇托桑微粒.
- 研究配方参数对粒子形态,稳定性和药物释放的影响.
- 评估这些微粒在局部药物输送和组织再生方面的潜力.
主要方法:
- 使用受控的离子凝 (800rpm,pH4.6) 制备了基托桑微粒.
- 物理化学表征涉及减弱总反射度里埃变换红外光谱 (ATR-FTIR),扫描电子显微镜 (SEM),动态光散射 (DLS) 和原子力显微镜 (AFM).
- 封装效率和体外药物释放研究使用牛血清白蛋白 (BSA) 进行.
主要成果:
- 配方参数影响了粒子形态和结构完整性.
- 鉴定证实了粒子形成,大小分布和表面特性.
- 实验室释放研究表明蛋白质释放率不同,在生理条件下 (PBS,pH7.4,37°C) 的配方之间稳定性有所不同.
结论:
- 通过离子凝制造的基托微粒表现出可调节的物理特性.
- 温和的制造条件和受控的药物释放能力凸显了它们的实用性.
- 这些微粒显示出作为局部药物输送的基质和作为组织再生的生物活性支架的巨大潜力.
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