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通过调节线粒体功能,MCEE促进了猪的肌肉内脂肪沉积

Yasai Li¹, Xinyue Chen², Dake Chen¹

¹Hubei Key Laboratory of Animal Embryo and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.

Animals : an open access journal from MDPI

|October 16, 2025

概括

基因MCEE通过改善线粒体功能来增强猪的肌肉内脂肪 (IMF) 沉积. 这一发现为改善肉类质量特征,如柔软性和风味提供了一个新的分子标.

科学领域:

动物科学动物科学
生物化学生物化学
遗传学是一个遗传学.

背景情况:

肌肉内脂肪 (IMF) 含量对肉类质量至关重要,影响软度,多汁度和风味.
规范国际货币基金组织存款的准确机制尚未完全理解.
以前的研究发现MCEE是与猪的IMF含量相关的候选基因.

研究的目的:

研究MCEE基因在猪肌内脂肪沉积中的作用.
阐明MCEE影响脂肪生成和肉质的分子机制.

主要方法:

隔离和培养初级猪肌内预脂细胞.
获得和丧失MCEE功能的研究 (过度表达和淘汰).
转录组分析 (RNA-Seq) 和途径丰富分析.
评估线粒体功能 (ROS水平,膜潜力,孔隙开放).

主要成果:

MCEE过度表达促进了前脂肪细胞的增殖和分化,而MCEE倒置则抑制了这些过程.
转录组分析显示,MCEE影响与氧化酸化和线粒体功能相关的途径.
MCEE局部存在于线粒体中,其表达调节了线粒体活动,包括活性氧物种 (ROS) 生产和线粒体膜潜力.

结论:

MCEE在调节猪肌肉内脂肪沉积方面发挥着重要作用.
MCEE通过调节线粒体功能来影响IMF沉积.
MCEE代表了提高牲畜肉质量的潜在分子标.

关键词:

中东欧和中东欧国家.肌肉内脂肪肌肉内脂肪肉质肉质肉质肉质猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪

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