长跨基因非编码RNA00511 (LINC00511) 乳腺癌的遗传变异和哈普洛型:一个病例对照研究和生物信息学分析
Shorouk Eldash1,2, Eman F Sanad3, Reham A A Elshimy4
1Pharmacology and Biochemistry Department, Faculty of Pharmacy, The British University in Egypt (BUE), El-Sherouk, Cairo 11837, Egypt.
International journal of molecular sciences
|October 16, 2025
概括
长跨基因非编码RNA 00511 (LINC00511) 中的单核酸多态 (SNP) 可能会增加乳腺癌 (BC) 的风险. LINC00511 SNP rs11657109显著与埃及妇女的较高BC发病率有关.
科学领域:
- 遗传学 遗传学 是一个
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 长跨基因非编码RNA 00511 (LINC00511) 涉及各种癌症,包括乳腺癌 (BC).
- 长非编码RNA (lncRNAs) 中的单核酸多态 (SNP) 与癌症的发展有关.
研究的目的:
- 调查特定的LINC00511SNP (rs11657109,rs9906859,rs17780195,rs1558535,rs4432291) 与埃及人口中乳腺癌发病率之间的关联.
主要方法:
- 一个病例控制研究涉及267个BC病例和150个对照.
- 使用后勤回归分析来评估LINC00511SNP与BC风险之间的关系.
主要成果:
- LINC00511 SNP rs11657109的TT基因型与乳腺癌发病率的增加显著相关 (OR: 2.177,95% CI: 1.260-3.763).
- 这种SNP特别与较高的光线A乳腺癌发病率有关.
- 一个特定的单元型 (A09A91A35G95T59) 与BC发病率的增加密切相关,在对照组中缺席.
结论:
- LINC00511 SNP rs11657109 是埃及人口乳腺癌易感性的潜在危险因素.
- 对lncRNA SNPs的进一步研究可以提供有关癌症病因和个性化风险评估的见解.
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