多发性骨髓瘤患者的移植:当前的证据,挑战和未来的方向
Natacha Rodrigues1,2, Manuel Silva1, Carolina Branco1,2
1Department of Nephrology and Renal Transplantation, Unidade de Saúde Local Santa Maria, 1649-028 Lisbon, Portugal.
International journal of molecular sciences
|October 16, 2025
概括
移植正在成为多发性骨髓瘤 (MM) 患者实现深度缓解的可行选择. 仔细的患者选择和随访对于成功的置换疗法至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 血液学 血液学 血液学
- 移植 移植 移植 移植
背景情况:
- 脏干扰是多发性骨髓瘤 (MM) 的重要并发症,影响结果和生活质量.
- 传统上,MM患者的末期病将他们排除在移植之外.
- 在MM疗法的进步已经改善了生存和响应的耐久性.
研究的目的:
- 审查目前关于MM患者脏移植的证据.
- 为接受脏移植的MM患者提出基于证据的资格标准.
- 概述移植后管理的治疗策略.
主要方法:
- 对MM患者移植的最新证据的文献综述.
- 基于移植前缓解深度的生存结果分析.
- 综合治疗策略进行长期随访.
主要成果:
- 报告的5年全移植存活率在50-66%之间.
- 无进展生存率为44%,整体生存率为61%.
- 结果取决于移植前缓解的深度.
结论:
- 移植是仔细选择的MM患者在深度,持续缓解的可行选择.
- 需要进一步的前性研究来验证这些发现.
- 这种方法为符合条件的MM患者提供了潜在的替代疗法选择.
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