相关实验视频
Updated: Jan 15, 2026

07:17
Studying Orthodontic Tooth Movement in Mice
Published on: August 2, 2024
1.4K
骨质细胞在正统牙牙运动中的作用的最新进展
Aseel Marahleh1,2, Fumitoshi Ohori1, Jinghan Ma1
1Division of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Tohoku University, 4-1, Seiryo-Machi, Aoba-ku, Sendai 980-8575, Miyagi, Japan.
International journal of molecular sciences
|October 16, 2025
概括
骨细胞,骨细胞感知力,驱动骨重塑为正牙移动 (OTM). 衰老影响骨细胞功能,影响治疗结果.
科学领域:
- 生物医学工程 生物医学工程
- 细胞生物学 细胞生物学
- 矯正牙科 矯正牙科是一種矯正牙科.
背景情况:
- ортодонтика牙移动 (OTM) 涉及复杂的骨重塑.
- 骨细胞是骨基内关键机械敏感细胞.
- 了解骨细胞的作用对于优化OTM至关重要.
研究的目的:
- 审查骨质细胞在OTM中的多方面的作用.
- 为了检查骨质细胞参与炎症,机械适应和细胞死亡在OTM.
- 探索衰老如何影响骨细胞功能和OTM.
主要方法:
- 在OTM中对骨细胞功能的文献综述.
- 分析骨质细胞在骨再吸收和机械传导中的作用.
- 讨论衰老效应和骨细胞形态适应.
主要成果:
- 骨细胞是信号通路的核心,在OTM期间调解骨的再吸收.
- 与衰老相关的衰老会破坏骨细胞机械感知和骨重塑.
- 骨细胞的结构性可塑性可能会导致OTM结果变化.
结论:
- 骨细胞信号传递对OTM至关重要.
- 准骨质细胞通路可以增强正牙治疗.
- 对骨细胞适应的进一步研究是个性化正义牙科所需要的.
相关概念视频
Osteoclasts in Bone Remodeling
3.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.9K
Bone Remodeling
40.2K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.2K
Bone Cells and Tissue
8.0K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
8.0K
Tooth Anatomy
2.0K
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
2.0K
Bone Formation by Intramembranous Ossification
10.1K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
10.1K
Bone Formation by Endochondral Ossification
8.4K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
8.4K

