暴露于双B和S会增加中年男性生殖功能障碍的风险
Sen Zhao1, Heliang Ni1, Yuan Xiao1
1College of Bioscience and Biotechnology, Shenyang Agricultural University, Shenyang 110866, China.
International journal of molecular sciences
|October 16, 2025
概括
双B (BPB) 和双S (BPS) 积聚在丸中,破坏类固醇生成,并在中年男性中引起男性生殖功能障碍 (MRD). 这些发现为双安全性评估提供了洞察力.
科学领域:
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
- 分子生物学分子生物学
背景情况:
- 双A (BPA) 的类似物如双B (BPB) 和双S (BPS) 与男性生殖功能障碍 (MRD) 有关.
- 在中年男性中,BPA类似物在MRD中的作用尚不清楚.
- 代表性的MRD疾病包括密码症,勃起功能障碍,早泄和丸瘤.
研究的目的:
- 研究BPB和BPS在中年男性中诱导MRD的分子机制.
- 为了确定受双暴露影响的核心分子标和途径.
- 为BPB和BPS的安全评估提供数据.
主要方法:
- 使用GeneCards,STRING和Cytoscape进行生物信息分析,以识别枢纽基因 (TP53,AKT1,MYC).
- 丰富分析以确定破坏的途径 (类固醇生成).
- UPLC-MS/MS用于量化丸中的BPB和BPS积累.
- 在体内暴露的研究,以评估对水平和基因表达的影响.
- 分子对接以预测与细胞P450酶的相互作用.
主要成果:
- 确定TP53,AKT1和MYC是与MRD相关的核心目标.
- 发现双 (BPs) 破坏了类固醇生成.
- 在丸组织中积聚BPB和BPS.
- 暴露于BPB或BPS降低了丸激素水平和枢纽基因表达.
- 分子对接证实BPB和BPS与细胞染色体P450酶结合,可能抑制性激素合成.
结论:
- 在中年男性中,BPB和BPS通过破坏类固醇生成并积聚在丸中来诱导MRD.
- 鉴定的分子标和途径提供了对双诱导的生殖毒性的机制性理解.
- 这些发现对于评估与BPB和BPS暴露相关的生殖健康风险至关重要.
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